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HEAD-TO-TOE SKIN HEALTH TRIO

4.7
(6,671)

Hydrating face, eye, and body care that smooths + firms.

  • Age-Reversal Peptide
  • Smoothing
  • Firming
  • Fragrance Free
head to toe skin health trio
HEAD-TO-TOE SKIN HEALTH TRIO
Three skincare bottles from ONE SKIN on a light gray textured background with promotional text describing resilience, smoothness, and lightweight hydration.
Before-and-after comparison of facial skin texture on the forehead, showing deep wrinkles and hyperpigmentation in the top panel labeled BEFORE, and smoother, clearer skin in the bottom panel labeled AFTER 12 WEEKS. Text on the right states '100% showed visibly smoother skin'.
Before-and-after comparison of skin texture on an arm, labeled 'BODY MOISTURIZER' with 'BEFORE' on the left and 'AFTER 12 WEEKS' on the right, showing visibly smoother texture.
Before-and-after comparison of an eye cream treatment on a person's eye area, showing skin texture and elasticity improvement over 12 weeks. The top panel is labeled 'BEFORE' and the bottom panel 'AFTER 12 WEEKS' with text stating '26% increase in elasticity'.
A close-up of a clear circular container filled with transparent gel or serum, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
Three skincare products from the brand One Skin, including a large pump bottle, a cylindrical bottle, and a small tube, displayed inside a clear zippered plastic bag with a black spatula tool on a white background.
head to toe skin health trio
HEAD-TO-TOE SKIN HEALTH TRIO
Three skincare bottles from ONE SKIN on a light gray textured background with promotional text describing resilience, smoothness, and lightweight hydration.
Before-and-after comparison of facial skin texture on the forehead, showing deep wrinkles and hyperpigmentation in the top panel labeled BEFORE, and smoother, clearer skin in the bottom panel labeled AFTER 12 WEEKS. Text on the right states '100% showed visibly smoother skin'.
Before-and-after comparison of skin texture on an arm, labeled 'BODY MOISTURIZER' with 'BEFORE' on the left and 'AFTER 12 WEEKS' on the right, showing visibly smoother texture.
Before-and-after comparison of an eye cream treatment on a person's eye area, showing skin texture and elasticity improvement over 12 weeks. The top panel is labeled 'BEFORE' and the bottom panel 'AFTER 12 WEEKS' with text stating '26% increase in elasticity'.
A close-up of a clear circular container filled with transparent gel or serum, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
Three skincare products from the brand One Skin, including a large pump bottle, a cylindrical bottle, and a small tube, displayed inside a clear zippered plastic bag with a black spatula tool on a white background.

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  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

Details
  • Smooth, visibly firm, and improve visible signs of aging with a hydrating trio for the eye area, face, and body powered by our proprietary OS-01 Senescence-Blocking Peptide™
  • OS-01 EYE CREAM improves elasticity and firmness while smoothing the appearance of fine lines and wrinkles1,2
  • OS-01 FACE MOISTURIZER visibly smooths and softens texture, evens skin tone, and strengthens skin's protective barrier3
  • OS-01 BODY MOISTURIZER targets a root cause of crepiness while visibly firming for younger-looking, healthier body skin4
  • Lightweight textures instantly absorb into skin with no residue
Clinical proof

OS-01 EYE CREAM 

  • +26% increase in elasticity after 3 months1
  • +27% increase in visible firmness after 12 months2
  • -18% reduction in the appearance of fine lines and wrinkles after 12 months2

OS-01 FACE MOISTURIZER 

  • 100% showed visibly smoother texture after 12 weeks3
  • 96% showed more even tone, radiance, and visible firmness after 12 weeks3
  • 91% had improved elasticity after 12 weeks3

OS-01 BODY MOISTURIZER 

  • +41% increase in skin’s barrier resilience after 12 weeks4
  • +38% increase in hydration after 12 weeks4
  • 70% reported visibly smoother texture and improved general appearance after 12 weeks4

The Clinical Studies

OS-01 EYE CREAM: 3-Month Efficacy Study1

A clinical study conducted by a third-party research organization evaluated the effects of OS-01 EYE CREAM over 3 months in 22 participants aged 47–65. Participants applied OS-01 EYE CREAM to their periorbital skin 2x daily. Assessments included bioinstrumental measurements of skin hydration, barrier function, firmness, and elasticity, as well as expert photographs grading fine lines, wrinkles, under-eye puffiness, and dark circles. The study has been published in the International Journal of Cosmetic Science.

Measured results:

  • +20 increase in hydration after 1 month; +32% increase in hydration after 3 months (Corenometer)
  • +14% increase in elasticity after 1 month; +26% increase in elasticity after 3 months (Cutometer)
  • +10% increase in firmness after 3 months (Cutometer)
  • +10% increase in barrier strength after 1 month; +17% increase in barrier strength after 3 months (Vapometer)

Consumer perception results:

  • 95% observed improved overall appearance after 3 months
  • 91% observed visibly more even tone and smoother texture after 3 months
  • 86% observed more radiant skin after 3 months
  • 82% observed visible improvements in firmness and elasticity after 3 months
  • 77% observed reduced visible eye puffiness after 3 months

OS-01 EYE CREAM: 12-Month Efficacy Study2

A clinical study conducted by a third-party research organization evaluated the effects of OS-01 EYE CREAM over 12 months in 23 participants aged 47–60. Participants applied OS-01 EYE CREAM to their periorbital skin 2x daily and results were assessed by expert clinical grading.

Expert Grading Results:

  • +19% increase in visible firmness after 6 months; +27% increase in visible firmness after 12 months (expert grading)
  • +23% increase in visible elasticity after 6 months; +29% increase in elasticity after 12 months (expert grading)
  • 18% reduction in the appearance of fine lines and wrinkles after 12 months (expert grading)

Consumer perception results:

  • 100% observed improved overall appearance after 12 months
  • 100% observed more radiant skin after 12 months
  • 96% observed visibly more even tone and smoother texture after 12 months
  • 95% observed improved firmness and elasticity after 12 months
  • 86% observed reduced appearance of eye bags after 12 months
  • 86% observed reduced appearance of visible dark spots after 12 months

OS-01 FACE MOISTURIZER: 3-Month Efficacy Study3 

A 12-week, third-party split-face, double-blind clinical study evaluated the effects of OS-01 FACE and the OS-01 Peptide™ in 22 female participants (ages 47–65) with dry, normal, and combination skin. Participants applied OS-01 FACE MOISTURIZER 2x daily to one side of the face and an identical peptide-free "vehicle" formula to the other, isolating the peptide's effect from the rest of the formulation. Barrier function, wrinkles, texture, and radiance were measured with instrumental devices (Vapometer, Antera 3D, VISIA CR), while fine lines/wrinkles, skin tone, texture, firmness, elasticity, radiance, and overall appearance were evaluated visually and tactiley by expert clinical graders. Published in the Journal of Cosmetic Dermatology, Zonari et al., 2024.

The results after 12 weeks:

  • 100% showed visibly smoother skin with improved overall appearance (blind expert grading)
  • 96% showed more even, radiant, and firmer-looking skin with less visible pores (blind expert grading)
  • 91% showed improved elasticity (blind expert grading)
  • 86% had reduced appearance of fine lines and wrinkles (blind expert grading)
  • +14% increase in barrier strength (Tewameter)
  • +17% improvement in visible radiance (VISIA-CR)

OS-01 BODY MOISTURIZER: 3-Month Efficacy Study4

A 12-week, double-blind, third-party clinical study evaluated the effects of OS-01 BODY MOISTURIZER on body skin hydration, barrier function, texture, and appearance. 60 participants were divided into two groups: one applied OS-01 BODY twice daily, while the other applied a placebo moisturizer twice daily. Hydration and trans-epidermal water loss (TEWL) were measured with instrumental devices (Corneometer and Tewameter). Participants also reported subjective improvements. Published in the Journal of Cosmetic Dermatology, Zonari et al., 2025.

The results after 12 weeks:

  • 93% of participants reported improved skin hydration
  • +38% improvement in forearm and upper arm hydration (corneometer)
  • +41% improvement in skin barrier on forearm and +35% on upper arm (tewameter)
  • 70% reported improved skin texture
  • 70% reported improved overall appearance

Safety studies

OS-01 FACE MOISTURIZER, OS-01 BODY MOISTURIZER OS-01 EYE CREAM are non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on their formulas and clinical testing, they have been awarded the National Eczema Association Seal of Acceptance™.

Our commitment to the scientific process

OneSkin products are validated with a rigorous process from the lab to the clinic: Lab testing on human skin to evaluate the effect on the cellular level, consumer testing with real users to ensure optimal texture and feel, and third-party clinical studies to evaluate the effect on the human level over time.
Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 EYE CREAM ingredients:
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum.
*OS-01 Peptide

OS-01 FACE MOISTURIZER ingredients:
Water (Aqua), Glycerin, Sorbitan Olivate, Helianthus Annuus (Sunflower) Seed Oil, Squalane, Cetearyl Olivate, Carapa Guianensis Seed Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba Seed Oil, Rosa Canina Fruit Oil, Prunus Domestica Seed Oil, Calycophyllum Spruceanum Bark Extract, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

OS-01 BODY MOISTURIZER ingredients:
Water (Aqua), Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Squalane, Avena Sativa (Oat) Kernel Oil, Prunus Domestica Seed Oil, Cetearyl Olivate, Mangifera Indica (Mango) Seed Butter, Saccharide Isomerate, Panthenol, Tremella Fuciformis Sporocarp Extract, Tocopheryl Acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NG, Galactoarabinan, Lepidium Sativum Sprout Extract, Soy Isoflavones, Niacinamide, Betaine, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin,  Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

This set includes

Clear bottle with black pump and 'One Skin' label on a light beige background

STEP 1

OS-01 EYE CREAM

Nourishing hydration that improves elasticity + firmness.

Size

20 mL / .67 fl oz

How to use

Gently tap 1⁄2-1 pump around each eye.

Skincare bottle labeled 'One Skin' on a beige background

STEP 2

OS-01 FACE MOISTURIZER

Lightweight hydration clinically shown to firm and smooth skin.

Size

50 mL / 1.7 fl oz

How to use

Gently massage 1-2 pumps into the face, neck, and chest.

White bottle with black pump and 'One Skin' logo on a beige background

STEP 3

OS-01 BODY MOISTURIZER

Nourishing hydration designed to strengthen crepey skin.

Size

250 mL / 8.45 fl oz

How to use

Apply to arms, legs, chest, back, and stomach and massage until absorbed. Use 2x daily.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.5

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →

Clinically validated results that build over time.

Before-and-after comparison of under-eye dark circles on a person's face, with the top labeled BEFORE and the bottom labeled AFTER 12 WEEKS. The image shows close-up views of the left eye area with a dotted circle highlighting the skin region.

95%

reported smoother-looking and more even toned skin after 4 weeks2

Before-and-after comparison of a person's eye area showing skin texture and wrinkles around the eye, with text reading 'BEFORE' and 'AFTER 12 WEEKS' on a beige sidebar.

95%

reported improved overall appearance after 12 weeks2

Before-and-after comparison of a closed eye showing skin texture and wrinkles around the eyelid, with dotted white outlines highlighting the treated area. The top panel is labeled BEFORE and the bottom panel is labeled AFTER 12 WEEKS.

86%

had improved elasticity after 12 weeks2

WEEK 1

Instant hydration you can feel 

  • OS-01 Peptide™  gets to work reversing the visible effects of senescent (dysfunctional, aging) cells
  • Supporting ingredients instantly hydrate and smooth
  • Caffeine visibly stimulates circulation
Month 1

Visibly smoother, firmer, more-even-toned skin

  • +20% boost in hydration1
  • 95% observed visibly smoother texture and a more even tone1
  • 86% had improved elasticity after 12 weeks1
Month 12

Visibly healthier, firmer skin that looks, feels + acts younger

  • +27% improvement in visible firmness2
  • +29% improvement in visible elasticity2
  • -18% reduced appearance of fine lines and wrinkles 
  • +25% improved radiance2 
  • 95% saw improvements in general appearance2

Key ingredients

A thick, creamy white swatch of cosmetic cream or lotion on a solid black background.
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Moringa oleifera seed extract

Protects skin cells against environmental pollutants that can trigger visible skin aging.

Biomimetic vegan collagen

This biodesigned vegan collagen peptide visibly boosts elastin, laminin, collagen and fibronectin while most topical collagen fails to reach the deeper layers. 

Fucus vesiculosus algae extract

Helps reduce the appearance of dark circles and crow’s feet while enhancing overall skin luminosity.

All Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

OS-01 EYE CREAM ingredients:
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum.
*OS-01 Peptide

OS-01 FACE MOISTURIZER ingredients:
Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

Ingredients
Water (Aqua), Glycerin, Sorbitan Olivate, Helianthus Annuus (Sunflower) Seed Oil, Squalane, Cetearyl Olivate, Carapa Guianensis Seed Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba Seed Oil, Rosa Canina Fruit Oil, Prunus Domestica Seed Oil, Calycophyllum Spruceanum Bark Extract, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.

OS-01 BODY MOISTURIZER ingredients:
Water (Aqua), Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Squalane, Avena Sativa (Oat) Kernel Oil, Prunus Domestica Seed Oil, Cetearyl Olivate, Mangifera Indica (Mango) Seed Butter, Saccharide Isomerate, Panthenol, Tremella Fuciformis Sporocarp Extract, Tocopheryl Acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NG, Galactoarabinan, Lepidium Sativum Sprout Extract, Soy Isoflavones, Niacinamide, Betaine, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin,  Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

OneSkin Longevity Protocol

HEAD-TO-TOE SKIN HEALTH TRIO

Write a Review (Opens in a new window)
6,671 reviews
  • SH
    Susan H.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    4 minutes ago
    Wonderful moisturizer

    I was getting crepy skin on my arms and legs. This moisturizer has done wonders to bring back my youthful looking skin! Highly recommend it.

    Was this helpful?
  • TR
    Teresa R.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    18 hours ago
    Body Moisturizer

    I love it. I saw a difference in less than a week. I could actually see it working.

    Was this helpful?
  • T
    Tawnya
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 4 out of 5 stars
    20 hours ago
    4 Stars

    Great, but too exoensive

    Was this helpful?
  • LR
    leigh r.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    20 hours ago
    Great for the body!

    The body moisturizer was where I started and that was just the beginning.... My natural skin tone has been restored and my skin, arms, stomach, legs look younger, more vibrant. If you have not tried it......you maybe missing something. I was.

    Was this helpful?
  • KS
    Krystal S.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    22 hours ago
    Obsessed

    The best. Order is on repeat.

    Was this helpful?
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Citations

  1. Based on a third-party 12-week clinical study with 22 participants aged 47–65. (Zonari, A., et al. International Journal of Cosmetic Science, 2025.) 
  2. Based on a third-party 12-month clinical study with 23 participants aged 47–60. 
  3. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.) 
  4. Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025.)
  5. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)